Creator: Stanford University
Folding@home is possibly the most successful GPGPU application at the moment, with ATI pioneering GPU-based folding years ago with its Radeon X1000 range of GPUs. Since then, folding has spread to the point where Nvidia has supported folding on all GPUs since its GeForce 8-series.
Folding is a client-based distributed computing application that simulates protein folding to aid our understanding of complex diseases such as Alzheimer's, Mad Cow Disease (BSE), CJD, ALS, Huntington's, Parkinson's disease, and many Cancers and cancer-related syndromes. To add some interest to the furthering of scientific and medical research doesn't hold any interest for you, Stanford also has team- and user-based 
leaderboards, so folding is also a competition.
To fold on your GPU, visit the 
High Performance Client page and download the latest version. The client downloads work units (aka 'projects') from Stanford, and each work unit is worth a certain amount of points.
You can monitor your folding progress via the 
FahMon tool, which will calculate how quickly your card can get through the current work unit and extrapolates a points per day (ppd) figure. You can join the 
bit-tech and Custom PC folding team (currently 
ranked fifth in the world) by using the team number 35947. Your contribution is valued.
  
    
    
      - 
        Nvidia GeForce GTX 295 1,792MB
      
- 
        Nvidia GeForce GTX 285 1GB	 
      
- 
        Gainward Nvidia GeForce GTX 295 1,792MB
      
- 
        Nvidia GeForce GTX 275 896MB
      
- 
        ATI Radeon HD 4890 1GB
      
- 
        Sapphire Radeon HD 4890 1GB Atomic
      
- 
        ATI Radeon HD 4870 1GB
      
      
        - 
          
            13769
           
- 
          
            7552
           
- 
          
            7093
           
- 
          
            7001
           
- 
          
            3781
           
- 
          
            3199
           
- 
          
            2988
           
        
          0
        
        
          2500
        
        
          5000
        
        
          7500
        
        
          10000
        
        
          12500
        
        
          15000
        
       
     
    ppd (as measured through f@hmon)
   
 
  
    
    
      - 
        Gainward Nvidia GeForce GTX 295 1,792MB
      
- 
        ATI Radeon HD 4870 1GB
      
- 
        Nvidia GeForce GTX 285 1GB
      
- 
        Nvidia GeForce GTX 275 896MB
      
- 
        ATI Radeon HD 4890 1GB
      
- 
        Sapphire Radeon HD 4890 1GB Atomic
      
- 
        Nvidia GeForce GTX 295 1,792MB
      
Power at socket (W)
    
   
 
While the original GTX 295 proved to a champion Folder thanks to it's effective utilisation of both GPUs, the newer version's revised design has meant that Folding@home is no longer able to utilise both GPUs, with PPD and power consumption falling as a result. However, an update to Nvidia's Forceware drivers will soon correct this, making the GTX 295 a champion folder once again, but still at the cost of electricity bill shaking power consumption.
    
 
    
    
        
            
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